The Millers line up against the Foxes at DVS this evening looking to progress in the competition which has seen them knock out higher division opponents in the past few seasons with the likes of Derby, Sheffield Wednesday, Southampton and Wolves all disposed of.
The last time the two teams met, Rotherham knocked City out of the Johnstone Paints Trophy with a 2-0 win back in 2008.
To check out the head2head down the years, click here
Sven Goran-Eriksson's men arrive on the back of a 1-0 Midlands derby win at Coventry but without key players through injury, suspension and International duty.
Darius Vassell misses out due to a red card at the weekend and starts a three match suspension whilst Saturday's goalscorer Lee Peltier is a major doubt.
Sean St. Ledger, Andy King and Yuke Abe are all away with their countries.
The Millers are missing Troy Brown who is on Welsh duty with latest signing Michael Raynes set to make his debut. Goalkeeper Conrad Logan also sits this one out as he cannot face his parent club as part of the terms of his loan, so Andy Warrington will play.
Ollie Banks returns to the fray after a groin problem.
The other absentee's are long term injury victims Jamie Annerson and Johnny Mullins, but boss Andy Scott may make changes to the side that won 1-0 against Oxford with Ben Pringle and Marcus Marshall waiting for starting spots.
It's back to the seven substitutes for this competition after the Football League revoked it's bench numbers to five for all npower matches.
Kick off is 7.45pm, with tickets priced at £10 and £5 on the gate.