Cresswell has missed the last eight games with an ankle ligament problem and despite the club initially ruling out surgery, another scan has indicated the recovery time is behind schedule.
Meanwhile Raynes, who missed Saturdays 2-0 win over Aldershot, will be absent for the weekend FA Cup tie at Barrow and the league match at Bradford the following week having been carried off at Northampton with muscle damage to his calf and knee.
Johnny Mullins was left on the bench at the weekend as a precaution to a minor knock with Jason Taylor filling in at centre half.
Meanwhile the Millers are awaiting confirmation that Guy Branston is cup tied ahead of their trip to Cumbria. He will definitely miss the Bradford game on the 19th as part of the terms of his loan deal.